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Asthma is a chronic inflammation of the bronchi characterized by recurrent breathing problems. During the normal breath, the air goes in and out freely from the lungs. But during an asthma attack, the lining of the airways thickens, the muscles around the airways tighten and mucus clogs the tiny airways in the lungs, making breathing difficult. The airways become hypersensitive to environmental changes, causing wheezing and coughing. Asthma symptoms vary from hour to hour, day by day, week by week and month. Often worse at night and early morning hours. The severity of asthma varies from individual to individual. Some patients have occasional symptoms (for example, after strenuous exercise), others have symptoms that interfere with their daily lives, others have asthma so severe that virtually prevents them from normal school activities or work.
People with asthma have airways that are contracted much more easily than non-asthmatics and are generally allergic to inhaled allergens. The causes of the abnormality of the airway and the relationship between this abnormality and the development of allergies are not known. A variety of factors can cause an asthma attack, including viral infections, exposure to allergens (eg. dust mites, protein particles secreted by cats and dogs, pollen), exercise, smoking; air pollution, strong emotions, chemical irritants, medications (aspirin and beta-blockers). Each person with asthma reacts to a different set of factors. The identification of these factors in an individual is first and foremost step towards the understanding and control of an asthma attack. Many researchers are investigating the role of genetic factors in the onset of asthma.
The World Health Organization has estimated that worldwide there are between 100 and 150 million people with asthma, and this number is growing. Worldwide, deaths due to asthma have reached 180,000 cases per year. Asthma is a public health problem both in developed countries than in developing countries. It occurs in all age groups and in all ethnic groups. However, often begins in childhood. Asthma is certainly the most common cause of school absences.
The rapid rise in asthma cases worldwide is one of the greatest mysteries of modern medicine. The most striking increase has been in Australia, where about a quarter of children are diagnosed as asthmatic. In the U.S., the number of people with asthma has more than doubled to 17.3 million estimate of asthma in 1998 compared with 6.7 million in 1980. The research into the causes has focused on factors such as allergens in environment and viral infections in infants and children. Ten years ago, scientists thought that diesel exhaust and other pollutants might be causing the asthma epidemic. However, they now believe that the picture is more complex. In addition to investigating the role of genetic factors in the development of asthma, researchers now are focusing on the immune system in early life.
The information needed for a diagnosis of asthma are provided by a careful medical history, physical examination and the patient's pulmonary function tests. Symptoms include wheezing, shortness of breath, chest tightness and cough particularly at night and worse in the early hours of the morning. Symptoms occur or are exacerbated in the presence of exercise, allergens, irritants and viral infections. Young children, whose symptoms are mainly the presence of a cough or shortness of breath in the course of a respiratory infection, are often incorrectly diagnosed, and classified as bronchitis or pneumonia patients (including ARI, acute respiratory infection ), then, are treated inadequately with antibiotics or cough suppressants. Smokers and the elderly frequently suffer from COPD, Bronchial Chronic Obstructive Pulmonary Disease, whose symptoms are similar to asthma. Sometimes asthma can be effectively and therefore benefit from drug treatment.
The pulmonary function tests are useful both for diagnosis and monitoring of asthma over time. These tests include spirometry, which provides a framework on the restriction of breathing capacity, and peak flow, to measure the maximum speed at which air escapes from the lungs. Spirometry is generally carried out in specialist clinics. On the other hand, the flow meters (peak flow meters) are portable, plastic and ideal for use both at home and at work, therefore, provide the majority of patients and physicians an effective method to evaluate response to therapy and detect the early stages of deterioration of asthma.
Asthma control can be achieved by implementing an effective disease management program: